Trusted Prescription Drug Information

• Take Xenical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Xenical is usually taken with each main meal that contains fat. Orlistat can be taken during meals or up to one hour after a meal.
• Each time you take Xenical, your meal should contain no more than about 30% of calories from fat. Evenly divide your daily intake of fat, carbohydrates, and protein over three main meals a day. Talk to your doctor about following a healthy eating plan.
• If you miss a meal, or if you have a meal without fat, you can skip your dose of orlistat for that meal also.
• If Xenical is taken with any one meal that is very high in fat, there is an increased chance of digestive side effects.
• Do not take more of this medication than has been prescribed for you. Doses greater than 120 mg three times a day have not been shown to provide an additional weight-loss benefit.
• Xenical may decrease your body’s absorption of some fat-soluble vitamins. To ensure adequate nutrition, your doctor may recommend taking a multivitamin that contains vitamins D, E, K, and beta-carotene. Take your vitamin supplement once a day, at least 2 hours before or after a dose of orlistat.
• Store orlistat at room temperature away from moisture and heat.